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KMID : 0387720220330010039
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Korean Journal of Blood Transfusion
2022 Volume.33 No. 1 p.39 ~ p.45
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Three Cases of Anti-LW Antibody Identification at a Tertiary Hospital in Korea
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Chae Seung-Wan
Kim Kyoung-Bo
Yu Hae-In
Choi Hwa-Jin
Jekarl Dong-Wook
Lim Ji-Hyang
Kim Yong-Goo
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Abstract
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The Landsteiner?Wiener (LW) antigen is a type of red blood cell antigen. Anti-LW appears in various situations, including alloantibodies, autoantibodies, and even transiently occurring antibodies. Anti-LW has similar characteristics to anti-D, so it can interfere with interpreting pre-transfusion tests and finding compatible blood. This paper introduces three cases in whom anti-LW was detected through antibody identification tests. All three cases were examined using the column agglutination technique with ID-DiaPanel (Bio-Rad, Hercules, CA, USA) on a LISS/Coombs card, ID-DiaPanel p (Bio-Rad) on a NaCl/Enzyme card, and ID-DiaPanel (Bio-Rad) on a LISS/Coombs card using red blood cells treated with dithiothreitol. The auto-control test, direct antiglobulin test, and umbilical cord blood test were also performed. In all three cases, the reaction with D-positive panel cells was stronger than that with the D-negative panel cells, and two of them showed a pan-agglutinated reaction in ID-DiaPanel p (Bio-Rad) with NaCl/Enzyme card. They were reported as anti-LW, and as in these cases, anti-LW can occur under a range of conditions and interfere with proper transfusion. Therefore, it is important to identify anti-LW accurately, and if anti-LW is present, the transfusion of D-negative ABO matched blood should be recommended because of the low expression of the LW-antigen. On the other hand, D-positive blood is not a contraindication when an urgent transfusion is needed
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KEYWORD
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Landsteiner-Wiener, Anti-LW, RBC antigen, Antibody identification
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